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Journal of Virology, December 1998, p. 10165-10170, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

HLA Compatibility Requirements for CD8+-T-Cell-Mediated Suppression of Human Immunodeficiency Virus Replication

Carl E. Mackewicz,1 Marvin R. Garovoy,2,dagger and Jay A. Levy1,*

Department of Medicine1 and Immunogenetics and Transplantation Laboratory, Department of Surgery,2 School of Medicine, University of California, San Francisco, San Francisco, California 94143-1270

Received 14 July 1998/Accepted 1 September 1998

CD8+ T cells from human immunodeficiency virus (HIV)-infected individuals can suppress HIV replication in cultured CD4+ cells by a noncytotoxic mechanism. Efficient suppression of HIV replication (>90% reduction) does not require HLA class I or class II histocompatibility between the effector CD8+ T cells and the infected target CD4+ T cells. However, maximal control of HIV production occurs when the CD8+ effector cells and CD4+ target cells are syngeneic. In some cases, more than 20-fold fewer syngeneic CD8+ T cells were required to achieve the same degree of HIV inhibition as HLA-mismatched CD8+ T cells. The increased antiviral activity seen in the syngeneic setting did not map exclusively to either the HLA class I or class II locus. These findings suggest that genetic compatibility (potentially, but not necessarily, at the HLA class I and class II loci) regulates CD8+ T-cell noncytotoxic antiviral activity against infected CD4+ T cells.

* Corresponding author. Mailing address: Department of Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA 94143-1270. Phone: (415) 476-4071. Fax: (415) 476-8365. E-mail: jalevy{at}itsa.ucsf.edu.

dagger Present address: Xoma Corporation, Berkeley, CA 94170.

Journal of Virology, December 1998, p. 10165-10170, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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