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Journal of Virology, November 1998, p. 9380-9383, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Short Consensus Repeat Domain 1 of Decay-Accelerating Factor Is Required for Enterovirus 70 Binding

Timothy M. Karnauchow,1,dagger Sandra Dawe,1,Dagger Douglas M. Lublin,2 and Kenneth Dimock1,*

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5,1 and Division of Pathology, Washington University School of Medicine, St. Louis, Missouri 631102

Received 1 June 1998/Accepted 4 August 1998

Enterovirus 70 (EV70), like several other human enteroviruses, can utilize decay-accelerating factor (DAF [CD55]) as an attachment protein. Using chimeric molecules composed of different combinations of the short consensus repeat domains (SCRs) of DAF and membrane cofactor protein (CD46), we show that sequences in SCR1 of DAF are essential for EV70 binding. Of the human enteroviruses that can bind to DAF, only EV70 and coxsackievirus A21 require sequences in SCR1 for this interaction.

* Corresponding author. Mailing address: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Rd., Ottawa, Ontario, Canada K1H 8M5. Phone: (613) 562-5800, ext. 8311. Fax: (613) 562-5452. E-mail: kdimock{at}uottawa.ca.

dagger Present address: Clinical Microbiology Laboratories, University of Rochester Medical Center, Rochester, NY 14642.

Dagger Present address: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7.

Journal of Virology, November 1998, p. 9380-9383, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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