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Journal of Virology, November 1998, p. 9374-9379, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

RNA-Binding Activity of the E1B 55-Kilodalton Protein from Human Adenovirus Type 5

Jackie J. Horridge and Keith N. Leppard*

Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom

Received 1 June 1998/Accepted 13 August 1998

The human adenovirus 5 E1B 55-kDa protein is required for efficient nucleocytoplasmic transport of late viral mRNAs. This protein is shown to have RNA-binding activity which maps to a region of the protein with homology to a family of RNA-binding proteins and which has been shown previously to be essential for functionality of the protein in vivo.

* Corresponding author. Mailing address: Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom. Phone: (44) 1203 523579. Fax: (44) 1203 523701. E-mail: Keith.Leppard{at}warwick.ac.uk.

Journal of Virology, November 1998, p. 9374-9379, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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