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Journal of Virology, November 1998, p. 9345-9347, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

CD4+ T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced by Noninfectious Human Immunodeficiency Virus Type 1 Virions

A. W. Sylwester,1 J.-C. Grivel,1 W. Fitzgerald,1 J. L. Rossio,2 J. D. Lifson,2,* and L. B. Margolis1,*

Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1855,1 and Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC Frederick, Frederick, Maryland 21702-12012

Received 18 May 1998/Accepted 24 July 1998

We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4+ T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4+ T-cell depletion, consistent with mechanisms requiring productive infection.

* Corresponding author. Mailing address for J.D.L.: Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC Frederick, Frederick, MD 21702-1201. Phone: (301) 846-1408. Fax: (301) 846-5588. E-mail: lifson{at}avpvx1.ncifcrf.gov. Mailing address for L.B.M.: Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892-1855. Phone: (301) 496-6571. Fax: (301) 591-0813. E-mail: margolis{at}helix.nih.gov.

Journal of Virology, November 1998, p. 9345-9347, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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