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Journal of Virology, November 1998, p. 9345-9347, Vol. 72, No. 11
Laboratory of Cellular and Molecular
Biophysics, National Institute of Child Health and Human
Development, National Institutes of Health, Bethesda, Maryland
20892-1855,1 and
Laboratory of
Retroviral Pathogenesis, AIDS Vaccine Program, SAIC Frederick,
Frederick, Maryland 21702-12012
Received 18 May 1998/Accepted 24 July 1998
We tested infectious human immunodeficiency virus type 1 (HIV-1),
noninfectious but conformationally authentic inactivated whole HIV-1
virions, and purified gp120 for the ability to induce depletion of
CD4+ T cells in human lymphoid tissues ex vivo. Infectious
CXCR4-tropic HIV-1, but not matched inactivated virions or gp120,
mediated CD4+ T-cell depletion, consistent with mechanisms
requiring productive infection.
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
CD4+ T-Lymphocyte Depletion in Human Lymphoid
Tissue Ex Vivo Is Not Induced by Noninfectious Human
Immunodeficiency Virus Type 1 Virions
*
Corresponding author. Mailing address for J.D.L.:
Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC
Frederick, Frederick, MD 21702-1201. Phone: (301) 846-1408. Fax: (301)
846-5588. E-mail: lifson{at}avpvx1.ncifcrf.gov. Mailing
address for L.B.M.: Laboratory of Cellular and Molecular Biophysics,
National Institute of Child Health and Development, National Institutes
of Health, Bethesda, MD 20892-1855. Phone: (301) 496-6571. Fax: (301)
591-0813. E-mail: margolis{at}helix.nih.gov.
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