JVI Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sylwester, A. W.
Right arrow Articles by Margolis, L. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sylwester, A. W.
Right arrow Articles by Margolis, L. B.

 Previous Article  |  Next Article 

Journal of Virology, November 1998, p. 9345-9347, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

CD4+ T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced by Noninfectious Human Immunodeficiency Virus Type 1 Virions

A. W. Sylwester,1 J.-C. Grivel,1 W. Fitzgerald,1 J. L. Rossio,2 J. D. Lifson,2,* and L. B. Margolis1,*

Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1855,1 and Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC Frederick, Frederick, Maryland 21702-12012

Received 18 May 1998/Accepted 24 July 1998

We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4+ T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4+ T-cell depletion, consistent with mechanisms requiring productive infection.

* Corresponding author. Mailing address for J.D.L.: Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC Frederick, Frederick, MD 21702-1201. Phone: (301) 846-1408. Fax: (301) 846-5588. E-mail: lifson{at}avpvx1.ncifcrf.gov. Mailing address for L.B.M.: Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892-1855. Phone: (301) 496-6571. Fax: (301) 591-0813. E-mail: margolis{at}helix.nih.gov.

Journal of Virology, November 1998, p. 9345-9347, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1998 by the American Society for Microbiology. All rights reserved.