Use of Coreceptors Other Than CCR5 by Non-Syncytium-Inducing Adult and Pediatric Isolates of Human Immunodeficiency Virus Type 1 Is Rare In Vitro

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Journal of Virology, November 1998, p. 9337-9344, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Use of Coreceptors Other Than CCR5 by Non-Syncytium-Inducing Adult and Pediatric Isolates of Human Immunodeficiency Virus Type 1 Is Rare In Vitro

Yi-jun Zhang,¹ Tatjana Dragic,¹ Yunzhen Cao,¹ Leondios Kostrikis,¹ Douglas S. Kwon,² Dan R. Littman,²^,³ Vineet N. KewalRamani,² and John P. Moore¹^,^*

Aaron Diamond AIDS Research Center, The Rockefeller University,¹ and The Skirball Institute of BioMolecular Medicine,² and Howard Hughes Medical Institute,³ New York University School of Medicine, New York, New York 10016

Received 1 June 1998/Accepted 4 August 1998

We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the abilityto employ the following proteins as coreceptors during viral entry:CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1,V28, US28, and APJ. Most non-syncytium-inducing isolates couldutilize only CCR5. All syncytium-inducing viruses used CXCR4,some also employed V28, and one (DH123) used CCR8 and APJ as well.A longitudinal series of HIV-1 subtype B isolates from an infectedinfant and its mother utilized Bonzo efficiently, as well as CCR5.The maternal isolates, which were syncytium inducing, also usedCXCR4, CCR8, V28, and APJ.

^* Corresponding author. Mailing address: Aaron Diamond AIDS Research Center, 455 1st Ave., 7th floor, New York, NY 10016. Phone:(212) 725-0018. Fax: (212) 725-1126. E-mail: jmoore{at}adarc.org.

Journal of Virology, November 1998, p. 9337-9344, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

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