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Journal of Virology, November 1998, p. 9323-9328, Vol. 72, No. 11
Institut für Medizinische Mikrobiologie
und Hygiene1 and
Institut für
Pathologie,2 Universität Regensburg,
Regensburg, Germany
Received 1 May 1998/Accepted 11 August 1998
In every latently Epstein-Barr virus-infected cell the viral genes
EBER-1 and EBER-2 are transcribed by polymerase III. In lytically
infected cells in vivo the EBER genes could not be detected. However,
in cell culture downregulation could not be confirmed, and hence the
relevance of this shutdown to the replication of the virus was not
clear. We assayed the transcriptional activity of the EBER genes by
nuclear run-on assays with enriched lytically infected cells and
demonstrated that EBER-1 and EBER-2 are differentially downregulated on
the transcriptional level during the switch to lytic viral replication.
This downregulation was an early event during the lytic replication of
the virus.
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Epstein-Barr Virus Small RNA (EBER) Genes:
Differential Regulation during Lytic Viral Replication
*
Corresponding author. Mailing address: Institut
für Medizinische Mikrobiologie und Hygiene,
Universität Regensburg, Franz-Josef-Strauss-Allee 11, D-93053
Regensburg, Germany. Phone: 49 941 9446452. Fax: 49 941 944 6402. E-mail:
Fritz.Schwarzmann{at}klinik.uni-regensburg.de.
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