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Journal of Virology, November 1998, p. 9303-9306, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Use of a Prenylation Inhibitor as a Novel Antiviral Agent

Jeffrey S. Glenn,1,* James C. Marsters Jr.,2 and Harry B. Greenberg1,3

Division of Gastroenterology,1 and Department of Microbiology and Immunology,3 Stanford University School of Medicine and Veterans Administration Medical Center, Palo Alto, California 94305-5487, and Bioorganic Chemistry, Genentech Inc., South San Francisco, California 940802

Received 3 March 1998/Accepted 24 July 1998

No specific therapy exists for hepatitis delta virus (HDV), which can cause severe liver disease. Molecular genetic studies have implicated the prenylation site of large delta antigen as a critical determinant of HDV particle assembly. We have established a cell culture model which produces HDV-like particles, and we show that delta antigen prenylation can be pharmacologically inhibited by the prenylation inhibitor BZA-5B. Furthermore, BZA-5B specifically abolishes particle production in a dose-dependent manner. These results demonstrate that the use of such a prenylation inhibitor-based antiviral therapy may be feasible and identify a novel class of potential antiviral agents.

* Corresponding author. Mailing address: Department of Medicine, Division of Gastroenterology, MC 5487, Stanford University School of Medicine, MSLS, P-304, 1201 Welch Rd., Palo Alto, CA 94305-5487. Phone: (650) 723-6661. Fax: (650) 723-5488. E-mail: Jeffrey.glenn{at}stanford.edu.

Journal of Virology, November 1998, p. 9303-9306, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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