This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guerin-Danan, C.
Right arrow Articles by Andrieux, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guerin-Danan, C.
Right arrow Articles by Andrieux, C.

 Previous Article  |  Next Article 

Journal of Virology, November 1998, p. 9298-9302, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Development of a Heterologous Model in Germfree Suckling Rats for Studies of Rotavirus Diarrhea

C. Guerin-Danan,1 J. C. Meslin,1 F. Lambre,1 A. Charpilienne,2 M. Serezat,1 C. Bouley,3 J. Cohen,2 and C. Andrieux1,*

Unité d'Ecologie et de Physiologie du Système Digestif, Equipe Métabolites Bactériens et Santé,1 and Unité de Virologie Immunologie Moléculaire,2 INRA, 78352 Jouy-en-Josas Cedex, and Département Nutrition, Danone, Le Plessis Robinson 92350,3 France

Received 19 February 1998/Accepted 24 July 1998

Germfree suckling rats were infected with an SA11 rotavirus strain. Infected pups developed diarrhea associated with histopathological changes. The virus was detected in feces and in the small intestine. Cellular vacuolation was observed in the villi of the jejunum. These results provide a new model for further investigations of group A rotavirus infection.

* Corresponding author. Mailing address: UEPSD-MBS, INRA-Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France. Phone: 33 1 34 65 24 68. Fax: 33 1 34 65 24 62. E-mail: andrieux{at}biotec.jouy.inra.fr

Journal of Virology, November 1998, p. 9298-9302, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • McNeal, M. M., Sestak, K., Choi, A. H.-C., Basu, M., Cole, M. J., Aye, P. P., Bohm, R. P., Ward, R. L. (2005). Development of a Rotavirus-Shedding Model in Rhesus Macaques, Using a Homologous Wild-Type Rotavirus of a New P Genotype. J. Virol. 79: 944-954 [Abstract] [Full Text]  
  • Boshuizen, J. A., Reimerink, J. H. J., Korteland-van Male, A. M., van Ham, V. J. J., Koopmans, M. P. G., Buller, H. A., Dekker, J., Einerhand, A. W. C. (2003). Changes in Small Intestinal Homeostasis, Morphology, and Gene Expression during Rotavirus Infection of Infant Mice. J. Virol. 77: 13005-13016 [Abstract] [Full Text]  
  • Mori, Y., Borgan, M. A., Ito, N., Sugiyama, M., Minamoto, N. (2002). Diarrhea-Inducing Activity of Avian Rotavirus NSP4 Glycoproteins, Which Differ Greatly from Mammalian Rotavirus NSP4 Glycoproteins in Deduced Amino Acid Sequence, in Suckling Mice. J. Virol. 76: 5829-5834 [Abstract] [Full Text]  
  • Ciarlet, M., Conner, M. E., Finegold, M. J., Estes, M. K. (2002). Group A Rotavirus Infection and Age-Dependent Diarrheal Disease in Rats: a New Animal Model To Study the Pathophysiology of Rotavirus Infection. J. Virol. 76: 41-57 [Abstract] [Full Text]  
  • Guérin-Danan, C., Meslin, J.-C., Chambard, A., Charpilienne, A., Relano, P., Bouley, C., Cohen, J., Andrieux, C. (2001). Food Supplementation with Milk Fermented by Lactobacillus casei DN-114 001 Protects Suckling Rats from Rotavirus-Associated Diarrhea. J. Nutr. 131: 111-117 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»