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Journal of Virology, November 1998, p. 9286-9290, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Murine Coronavirus-Induced Subacute Fatal Peritonitis in C57BL/6 Mice Deficient in Gamma Interferon

Shigeru Kyuwa,1,* Yoh-ichi Tagawa,2 Shinwa Shibata,3 Kunio Doi,3 Kenji Machii,4 and Yoichiroh Iwakura2

Department of Animal Pathology1 and Laboratory Animal Research Center,2 Institute of Medical Science, University of Tokyo, Tokyo 108, Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Tokyo 113,3 and Department of Veterinary Public Health, Institute of Public Health, Tokyo 108,4 Japan

Received 14 May 1998/Accepted 22 July 1998

Gamma interferon-deficient (IFN-gamma -/-) mice with a C57BL/6 background were infected intraperitoneally with mouse hepatitis virus strain JHM (JHMV). In contrast to IFN-gamma -+/- and IFN-gamma +/+ mice, JHMV persisted in IFN-gamma -/- mice and induced death during the subacute phase of the infection. Unexpectedly, infected IFN-gamma -/- mice showed severe peritonitis accompanying the accumulation of a viscous fluid in the abdominal and thoracic cavities in the subacute phase. Destructive changes of hepatocytes were not observed. Administration of recombinant IFN-gamma protracted the survival time of IFN-gamma -/- mice after JHMV infection. These results demonstrate that IFN-gamma plays a critical role in viral clearance in JHMV infection. They also show that a resultant persistent JHMV infection induces another form of disease in IFN-gamma -/- mice, which bears a resemblance to feline infectious peritonitis in cats.

* Corresponding author. Present address: Center for Animal Resources and Development, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan. Phone: 96-373-5360. Fax: 96-373-5375. E-mail: kyuwa{at}gpo.kumamoto-u.ac.jp.

Journal of Virology, November 1998, p. 9286-9290, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Navas, S., Weiss, S. R. (2003). Murine Coronavirus-Induced Hepatitis: JHM Genetic Background Eliminates A59 Spike-Determined Hepatotropism. J. Virol. 77: 4972-4978 [Abstract] [Full Text]  


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