This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Power, C.
Right arrow Articles by Peeling, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Power, C.
Right arrow Articles by Peeling, J.

 Previous Article  |  Next Article 

Journal of Virology, November 1998, p. 9109-9115, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Neurovirulence in Feline Immunodeficiency Virus-Infected Neonatal Cats Is Viral Strain Specific and Dependent on Systemic Immune Suppression

C. Power,1,* R. Buist,2 J. B. Johnston,1 M. R. Del Bigio,3 W. Ni,1 M. R. Dawood,4 and J. Peeling3

Department of Clinical Neurosciences,1 University of Calgary, Calgary, Alberta T2N 4N1, and Departments of Radiology,2 Pathology,3 and Medical Microbiology,4 University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada

Received 13 May 1998/Accepted 6 August 1998

Feline immunodeficiency virus (FIV) is a lentivirus that causes immune suppression and neurological disease in cats. Among animal viruses, individual viral strains have been shown to be neurovirulent, but the role of viral strain specificity among lentiviruses and its relationship to systemic immune suppression in the development of neurological disease remains uncertain. To determine the extent to which different FIV strains caused neurological disease, FIV V1CSF and Petaluma were compared in ex vivo assays and in vivo. Both viruses infected and replicated in macrophage and mixed glial cell cultures at similar levels, but V1CSF induced significantly greater neuronal death than Petaluma in a neurotoxicity assay. V1CSF-infected animals showed significant neurodevelopmental delay compared to the Petaluma-infected and uninfected animals. Magnetic resonance spectroscopy studies of frontal cortex revealed significantly reduced N-acetyl aspartate/creatine ratios in the V1CSF group compared to the other groups. Cyclosporin A treatment of Petaluma-infected animals caused neurodevelopmental delay and reduced N-acetyl aspartate/creatine ratios in the brain. Reduced CD4+ and CD8+ cell counts were observed in the V1CSF-infected group compared to the uninfected and Petaluma-infected groups. These findings suggest that neurodevelopmental delay and neuronal injury is FIV strain specific but that systemic immune suppression is also an important determinant of FIV-induced neurovirulence.

* Corresponding author. Mailing address: Department of Clinical Neurosciences, University of Calgary, Heritage Medical Building, 107-3330 Hospital Dr., Calgary, AB Canada T2N 4N1. Phone: (403) 220-5011. Fax: (403) 283-8731. E-mail: power{at}ucalgary.ca.

Journal of Virology, November 1998, p. 9109-9115, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Zhu, Y., Vergote, D., Pardo, C., Noorbakhsh, F., McArthur, J. C., Hollenberg, M. D., Overall, C. M., Power, C. (2009). CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J. 23: 2928-2941 [Abstract] [Full Text]  
  • Maingat, F., Vivithanaporn, P., Zhu, Y., Taylor, A., Baker, G., Pearson, K., Power, C. (2009). Neurobehavioral Performance in Feline Immunodeficiency Virus Infection: Integrated Analysis of Viral Burden, Neuroinflammation, and Neuronal Injury in Cortex. J. Neurosci. 29: 8429-8437 [Abstract] [Full Text]  
  • Zhu, Y., Antony, J. M., Martinez, J. A., Glerum, D. M., Brussee, V., Hoke, A., Zochodne, D., Power, C. (2007). Didanosine causes sensory neuropathy in an HIV/AIDS animal model: impaired mitochondrial and neurotrophic factor gene expression. Brain 130: 2011-2023 [Abstract] [Full Text]  
  • Heit, B., Jones, G., Knight, D., Antony, J. M., Gill, M. J., Brown, C., Power, C., Kubes, P. (2006). HIV and Other Lentiviral Infections Cause Defects in Neutrophil Chemotaxis, Recruitment, and Cell Structure: Immunorestorative Effects of Granulocyte-Macrophage Colony-Stimulating Factor. J. Immunol. 177: 6405-6414 [Abstract] [Full Text]  
  • Zhu, Y., Antony, J., Liu, S., Martinez, J. A., Giuliani, F., Zochodne, D., Power, C. (2006). CD8+ lymphocyte-mediated injury of dorsal root ganglion neurons during lentivirus infection: CD154-dependent cell contact neurotoxicity.. J. Neurosci. 26: 3396-3403 [Abstract] [Full Text]  
  • Zhu, Y., Jones, G., Tsutsui, S., Opii, W., Liu, S., Silva, C., Butterfield, D. A., Power, C. (2005). Lentivirus Infection Causes Neuroinflammation and Neuronal Injury in Dorsal Root Ganglia: Pathogenic Effects of STAT-1 and Inducible Nitric Oxide Synthase. J. Immunol. 175: 1118-1126 [Abstract] [Full Text]  
  • Kubes, P., Heit, B., van Marle, G., Johnston, J. B., Knight, D., Khan, A., Power, C. (2003). In Vivo Impairment of Neutrophil Recruitment during Lentivirus Infection. J. Immunol. 171: 4801-4808 [Abstract] [Full Text]  
  • Zhang, K., Rana, F., Silva, C., Ethier, J., Wehrly, K., Chesebro, B., Power, C. (2003). Human Immunodeficiency Virus Type 1 Envelope-Mediated Neuronal Death: Uncoupling of Viral Replication and Neurotoxicity. J. Virol. 77: 6899-6912 [Abstract] [Full Text]  
  • Patrick, M. K., Johnston, J. B., Power, C. (2002). Lentiviral Neuropathogenesis: Comparative Neuroinvasion, Neurotropism, Neurovirulence, and Host Neurosusceptibility. J. Virol. 76: 7923-7931 [Full Text]  
  • Johnston, J. B., Power, C. (2002). Feline Immunodeficiency Virus Xenoinfection: the Role of Chemokine Receptors and Envelope Diversity. J. Virol. 76: 3626-3636 [Abstract] [Full Text]  
  • Johnston, J. B., Silva, C., Power, C. (2002). Envelope Gene-Mediated Neurovirulence in Feline Immunodeficiency Virus Infection: Induction of Matrix Metalloproteinases and Neuronal Injury. J. Virol. 76: 2622-2633 [Abstract] [Full Text]  
  • Johnston, J. B., Jiang, Y., van Marle, G., Mayne, M. B., Ni, W., Holden, J., McArthur, J. C., Power, C. (2000). Lentivirus Infection in the Brain Induces Matrix Metalloproteinase Expression: Role of Envelope Diversity. J. Virol. 74: 7211-7220 [Abstract] [Full Text]  
  • Vahlenkamp, T. W., De Ronde, A., Schuurman, N. N. M. P., van Vliet, A. L. W., van Drunen, J., Horzinek, M. C., Egberink, H. F. (1999). Envelope gene sequences encoding variable regions 3 and 4 are involved in macrophage tropism of feline immunodeficiency virus. J. Gen. Virol. 80: 2639-2646 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»