JVI Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stitz, L.
Right arrow Articles by Bilzer, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stitz, L.
Right arrow Articles by Bilzer, T.

Journal of Virology, November 1998, p. 8884-8892, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Functional Role for Neutralizing Antibodies in Borna Disease: Influence on Virus Tropism outside the Central Nervous Systemdagger

L. Stitz,1,* K. Nöske,1,Dagger O. Planz,1 E. Furrer,1 W. I. Lipkin,2 and T. Bilzer3,*

Institut für Impfstoffe, Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen,1 and Institut für Neuropathologie, Heinrich-Heine-Universität, Düsseldorf,3 Germany, and Laboratory for Neurovirology and Microbial Pathogenesis, University of California, Irvine, California2

Received 6 April 1998/Accepted 13 July 1998

Borna disease virus (BDV) is a negative-strand RNA virus that infects the central nervous systems (CNS) of warm-blooded animals and causes disturbances of movement and behavior. The basis for neurotropism remains poorly understood; however, the observation that the distribution of infectious virus in immunocompetent rats is different from that in immunoincompetent rats indicates a role for the immune system in BDV tropism: whereas in immunocompetent rats virus is restricted to the central, peripheral, and autonomic nervous systems, immunoincompetent rats also have virus in nonneural tissues. In an effort to examine the influence of the humoral immune response on BDV pathogenesis, we examined the effects of passive immunization with neutralizing antiserum in immunoincompetent rats. Serum transfer into immunoincompetent rats did not prevent persistent CNS infection but did result in restriction of virus to neural tissues. These results indicate that neutralizing antibodies may play a role in preventing generalized infection with BDV.


* Corresponding author. Mailing address for L. Stitz: Institut für Impfstoffe, Bundesforschungsanstalt für Viruskrankheiten der Tiere, Paul-Ehrlich-Str. 28, D-72076 Tübingen, Germany. Phone: 49 7071 967 250. Fax: 49 7071 967 105. E-mail: stitz{at}tue.bfav.de. Mailing address for T. Bilzer: Institut für Neuropathologie, Heinrich-Heine-Universität, Postfach 101007, 40001 Düsseldorf, Germany. Phone: 49 211 81 18658. Fax: 49 211 81 17804. E-mail: bilzer{at}uni-duesseldorf.de.

dagger Dedicated to Professor V. ter Meulen on the occasion of his 65th birthday.

Dagger Present address: Paul-Ehrlich-Institut, Langen, Germany.


Journal of Virology, November 1998, p. 8884-8892, Vol. 72, No. 11
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1998 by the American Society for Microbiology. All rights reserved.