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Journal of Virology, October 1998, p. 8437-8445, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Characterization of Simian-Human Immunodeficiency Virus Envelope Glycoprotein Epitopes Recognized by Neutralizing Antibodies from Infected Monkeys

Bijan Etemad-Moghadam,1 Gunilla B. Karlsson,1 Matilda Halloran,2 Ying Sun,1 Dominik Schenten,1 Mark Fernandes,1 Norman L. Letvin,2 and Joseph Sodroski1,3,*

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute,1 and Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center,2 Harvard Medical School, and Department of Immunology and Infectious Diseases, Harvard School of Public Health,3 Boston, Massachusetts

Received 26 March 1998/Accepted 15 June 1998

We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein epitopes recognized by neutralizing antibodies from monkeys recently infected by molecularly cloned simian-human immunodeficiency virus (SHIV) variants. The early neutralizing antibody response in each infected animal was directed mainly against a single epitope. This primary neutralizing epitope, however, differed among individual monkeys infected by identical viruses. Two such neutralization epitopes were determined by sequences in the V2 and V3 loops of the gp120 envelope glycoprotein, while a third neutralization epitope, apparently discontinuous, was determined by both V2 and V3 sequences. These results indicate that the early neutralizing antibody response in SHIV-infected monkeys is monospecific and directed against epitopes composed of the gp120 V2 and V3 variable loops.

* Corresponding author. Mailing address: JFB 824, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115. Phone: (617) 632-3371. Fax: (617) 632-4338. E-mail: joseph_sodroski{at}dfci.harvard.edu.

Journal of Virology, October 1998, p. 8437-8445, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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