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Journal of Virology, October 1998, p. 8425-8429, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Major Open Reading Frame of the beta 2.7 Transcript of Human Cytomegalovirus: In Vitro Expression of a Protein Posttranscriptionally Regulated by the 5' Region

Giovanna Bergamini,* Marko Reschke,dagger Maria Concetta Battista, Maria Cristina Boccuni, Fabio Campanini, Alessandro Ripalti, and Maria Paola Landini

Department of Clinical and Experimental Medicine, Division of Microbiology, University of Bologna, St. Orsola Hospital, Bologna, Italy

Received 11 May 1998/Accepted 10 July 1998

beta 2.7 is the major early transcript produced during human cytomegalovirus infection. This abundantly expressed RNA is polysome associated, but no protein product has ever been detected. In this study, a stable peptide of 24 kDa was produced in vitro from the major open reading frame (ORF), TRL4. Following transient transfection, the intracellular localization was nucleolar and the expression was posttranscriptionally inhibited by the 5' sequence of the transcript, which harbors two short upstream ORFs.

* Corresponding author. Mailing address: Department of Clinical and Experimental Medicine, Division of Microbiology, University of Bologna, St. Orsola Hospital, Via Massarenti 9, 40138 Bologna, Italy. Phone: 39-51-341652. Fax: 39-51-341632. E-mail: gioi{at}med.unibo.it.

dagger Present address: Institute for Virology, Philipps University, 35037 Marburg, Germany.

Journal of Virology, October 1998, p. 8425-8429, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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