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Journal of Virology, October 1998, p. 8362-8364, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Mx1-Based Resistance to Thogoto Virus in A2G Mice Is Bypassed in Tick-Mediated Virus Delivery

Johannes T. Dessensdagger and Patricia A. Nuttall*

Institute of Virology and Environmental Microbiology, Oxford OX1 3SR, United Kingdom

Received 2 April 1998/Accepted 16 June 1998

The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1+ A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.

* Corresponding author. Mailing address: NERC Institute of Virology and Environmental Microbiology, Mansfield Rd., Oxford OX1 3SR, United Kingdom. Phone: 44-1865-281631. Fax: 44-1865-281696. E-mail: pan{at}mail.nox.ac.uk.

dagger Present address: Department of Biology, Imperial College, London SW7 2BB, United Kingdom.

Journal of Virology, October 1998, p. 8362-8364, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Samuel, C. E. (2001). Antiviral Actions of Interferons. Clin. Microbiol. Rev. 14: 778-809 [Abstract] [Full Text]  


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