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Journal of Virology, October 1998, p. 8338-8343, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Functionally Distinct TATA Box Required for Late Progression through the Epstein-Barr Virus Life Cycle

Tricia R. Serio,1,dagger Niamh Cahill,1 Matthew E. Prout,1 and George Miller1,2,3,*

Department of Molecular Biophysics and Biochemistry,1 Department of Epidemiology and Public Health,2 and Department of Pediatric Infectious Diseases3 Yale University, New Haven, Connecticut 06520

Received 15 April 1998/Accepted 16 July 1998

During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this core promoter is, surprisingly, disrupted by a heterologous enhancer, suggesting that late gene expression is regulated through core promoter sequences located in a transcriptionally inert environment.

* Corresponding author. Mailing address: 333 Cedar St., New Haven, CT 06520. Phone: (203) 785-4758. Fax: (203) 785-6961. E-mail: george_miller{at}qm.yale.edu.

dagger Present address: Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637.

Journal of Virology, October 1998, p. 8338-8343, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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