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J Virol, January 1998, p. 882-885, Vol. 72, No. 1
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Clearance of an Influenza A Virus by CD4+ T Cells Is Inefficient in the Absence of B Cells

David J. Topham and Peter C. Doherty*

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101-0318

Received 8 August 1997/Accepted 2 October 1997

The primary CD8+ T-cell response protected most B-cell-deficient µMT mice against intranasal infection with the HKx31 influenza A virus. Prior exposure did not prevent reinfection upon homologous challenge, and the recall CD8+ T-cell response cleared the virus from the lung within 7 days. Depleting the CD8+ T cells substantially reduced the capacity of these primed mice to deal with the infection, in spite of evidence for established CD4+ T-cell memory. Thus, the control of this relatively mild influenza virus by both primary and secondary CD4+ T-cell responses is relatively inefficient in the absence of B cells and CD8+ T cells.

* Corresponding author. Mailing address: 332 N. Lauderdale, Memphis, TN 38104-0318. Phone: (901) 495-3470. Fax: (901) 495-3107. E-mail: peter.doherty{at}stjude.org.




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