Glycoproteins gB, gD, and gHgL of Herpes Simplex Virus Type 1 Are Necessary and Sufficient To Mediate Membrane Fusion in a Cos Cell Transfection System

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J Virol, January 1998, p. 873-875, Vol. 72, No. 1
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Glycoproteins gB, gD, and gHgL of Herpes Simplex Virus Type 1 Are Necessary and Sufficient To Mediate Membrane Fusion in a Cos Cell Transfection System

Angelina Turner, Birgitte Bruun, Tony Minson, and Helena Browne^*

Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom

Received 21 August 1997/Accepted 3 October 1997

Herpes simplex virus type 1 glycoproteins gB, gD, and gHgL were expressed by transient transfection of Cos cells. Polykaryocyteformation above the background level seen in untransfected controlswas observed only if all three components were expressed. Thus,gB, gD, and gHgL are necessary and sufficient to induce membranefusion.

^* Corresponding author. Mailing address: Division of Virology, Department of Pathology, University of Cambridge, Tennis CourtRd., Cambridge CB2 1QP, United Kingdom. Phone: (1223) 336921.Fax: (1223) 336926. E-mail: hb100{at}mole.bio.cam.ac.uk.

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J. Bacteriol.	Mol. Cell. Biol.	Microbiol. Mol. Biol. Rev.

Clin. Vaccine Immunol.	ALL ASM JOURNALS