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J Virol, January 1998, p. 807-810, Vol. 72, No. 1
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Prophylactic Administration of a Complementarity-Determining Region Derived from a Neutralizing Monoclonal Antibody Is Effective against Respiratory Syncytial Virus Infection in BALB/c Mice

C. Bourgeois,^1,* J. B. Bour,¹ L. S. Aho,² and P. Pothier¹

Laboratoire de Microbiologie médicale et moléculaire, Faculté de Médecine, 21033 Dijon cedex,¹ and Service d'Epidémiologie et Hygiène hospitalière, CHUR du Bocage, 21034 Dijon cedex,² France

Received 2 July 1997/Accepted 15 October 1997

Immunotherapy with antibodies against respiratory syncytial virus (RSV) is a treatment option given the absence of any vaccine or other available satisfactory treatment. We selected one of our monoclonal antibodies, RS-348, that is highly neutralizing. We showed that a single peptide (PEP3H) derived from complementarity-determining region 3 (CDR3) of its heavy chain was capable of neutralizing the virus in vitro. When intranasally administered 24 h before challenge, this peptide protected BALB/c mice against RSV lung infection. These results indicate that a single CDR can be effective against RSV infection.

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^* Corresponding author. Mailing address: Laboratoire de Microbiologie médicale et moléculaire, Faculté de Médecine, Bld. Jeanne d'Arc, 21033 Dijon cedex, France. Phone: 33 3 80 29 38 56. Fax: 33 3 80 29 36 04.

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