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J Virol, January 1998, p. 789-795, Vol. 72, No. 1
Richard Dimbleby Department of Cancer
Research/ICRF Laboratory,
Received 13 May 1997/Accepted 24 September 1997
To generate transcriptionally targeted vectors, tissue-specific
elements of the human tyrosinase promoter were exchanged with corresponding viral elements in the Moloney murine leukemia virus long
terminal repeat (LTR). From these experiments, a vesicular stomatitis
virus type G pseudotyped, hybrid LTR vector that contained three
tyrosinase enhancer elements and gave high-level, tightly tissue-specific expression at high titers (3 × 107
CFU/ml) was constructed.
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Exchange of Viral Promoter/Enhancer Elements with
Heterologous Regulatory Sequences Generates Targeted Hybrid Long
Terminal Repeat Vectors for Gene Therapy of Melanoma
*
Corresponding author. Mailing address: ICRF Laboratory
of Molecular Therapy, ICRF Oncology Unit, Hammersmith Hospital, DuCane Rd., London, W12 0NN. Phone: 181 383 8584. Fax: 181 383 3258. E-mail:
R.Vile{at}icrf.icnet.uk.
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