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J Virol, January 1998, p. 767-771, Vol. 72, No. 1
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation?

Julia A. Beatty,1,* John J. Callanan,2,dagger Anne Terry,1 Oswald Jarrett,1 and James C. Neil1

Department of Veterinary Pathology, University of Glasgow, Bearsden, Glasgow G61 1QH, United Kingdom,1 and Department of Agriculture and Food, Regional Veterinary Laboratory, Bishopstown, Cork, Ireland2

Received 30 June 1997/Accepted 19 September 1997

We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a+, CD79b-, CD21-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.

* Corresponding author. Mailing address: Department of Veterinary Pathology, University of Glasgow, Bearsden Rd., Glasgow G61 1QH, United Kingdom. Phone: 141 339 8855. Fax: 141 330 5602. E-mail: J.Beatty{at}udcf.gla.ac.uk.

dagger Present address: Department of Veterinary Pathology, University College of Dublin, Faculty of Veterinary Medicine, Ballsbridge, Dublin 4, Ireland.




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Copyright © 1998 by the American Society for Microbiology. All rights reserved.