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J Virol, January 1998, p. 726-730, Vol. 72, No. 1
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Expression of the Mucosal Homing Receptor alpha 4beta 7 Correlates with the Ability of CD8+ Memory T Cells To Clear Rotavirus Infection

Jason R. Rosé,1,2,3,* Marna B. Williams,2,3,4,* Lusijah S. Rott,2,3,4 Eugene C. Butcher,2,3,4 and Harry B. Greenberg1,2,3

Departments of Medicine, Microbiology, and Immunology, Stanford University School of Medicine,1 and Laboratory of Immunology and Vascular Biology, Department of Pathology,4 and Digestive Disease Center,3 Stanford University, Stanford, California 94305, and Veterans Affairs Palo Alto Health Care System, Palo Alto, California 943042

Received 18 March 1997/Accepted 16 October 1997

The integrin alpha 4beta 7 plays an important role in lymphocyte homing to mucosal lymphoid tissues and has been shown to define a subpopulation of memory T cells capable of homing to intestinal sites. Here we have used a well-characterized intestinal virus, murine rotavirus, to investigate whether memory/effector function for an intestinal pathogen is associated with alpha 4beta 7 expression. alpha 4beta 7hi memory phenotype (CD44hi), alpha 4beta 7- memory phenotype, and presumptively naive (CD44lo) CD8+ T lymphocytes from rotavirus-infected mice were sorted and transferred into Rag-2 (T- and B-cell-deficient) recipients that were chronically infected with murine rotavirus. alpha 4beta 7hi memory phenotype CD8+ cells were highly efficient at clearing rotavirus infection, alpha 4beta 7- memory cells were inefficient or ineffective, depending on the cell numbers transferred, and CD44lo cells were completely unable to clear chronic rotavirus infection. These data demonstrate that functional memory for rotavirus resides primarily in memory phenotype cells that display the mucosal homing receptor alpha 4beta 7.

* Corresponding author. Mailing address: Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305-5487. Phone: (650) 493-5000, ext. 6-3122 (J. R. Rosé) or 6-3134 (M. B. Williams). Fax: (650) 852-3259 (J. R. Rosé) or (650) 858-3986 (M. B. Williams).




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