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J. Virol., 09 1997, 6863-6868, Vol 71, No. 9
Copyright © 1997, American Society for Microbiology

Cryo-electron microscopy structure of yeast Ty retrotransposon virus- like particles

KJ Palmer, W Tichelaar, N Myers, NR Burns, SJ Butcher, AJ Kingsman, SD Fuller and HR Saibil
Department of Crystallography, Birkbeck College, London, United Kingdom.

The virus-like particles (VLPs) produced by the yeast retrotransposon Ty1 are functionally related to retroviral cores. These particles are unusual in that they have variable radif. A paired mass-radius analysis of VLPs by scanning transmission electron microscopy showed that many of these particles form an icosahedral T-number series. Three- dimensional reconstruction to 38-A resolution from cryo-electron micrographs of T = 3 and T = 4 shells revealed that the single structural protein encoded by the TYA gene assembles into spiky shells from trimeric units.


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