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J. Virol., Aug 1997, 6230-6232, Vol 71, No. 8
Copyright © 1997, American Society for Microbiology

Upregulation of human immunodeficiency virus (HIV) replication by CD4 cross-linking in peripheral blood mononuclear cells of HIV-infected adults

S Than, N Oyaizu, S Tetali, J Romano, M Kaplan and S Pahwa
Department of Pediatrics, North Shore University Hospital-New York University School of Medicine, Manhasset 11030, USA.

This study was conducted with peripheral blood mononuclear cells from 67 human immunodeficiency virus (HIV)-infected adults. It supports the hypothesis that cross-linking of CD4 molecules by HIV gp120 can result in HIV upregulation and spread of infection. Underlying mechanisms include activation of latent infection by factors in addition to, or other than, tumor necrosis factor alpha.


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