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J. Virol., 07 1997, 5658-5662, Vol 71, No. 7
Copyright © 1997, American Society for Microbiology

Rhabdovirus-induced apoptosis in a fish cell line is inhibited by a human endogenous acid cysteine proteinase inhibitor

HV Bjorklund, TR Johansson and A Rinne
Institute of Parasitology, Department of Biology, Abo Akademi University, Turku, Finland. harry.bjorklund@bmc.uu.se

To determine the mechanisms of cell death in rhabdovirus-infected cells, we studied the infection of the epithelial papilloma of carp cell line with spring viremia of carp virus. Studies using electron microscopy, confocal microscopy, and agarose gel electrophoresis revealed changes in cell morphology and DNA fragmentation indicative of apoptosis. The virus-induced apoptosis was inhibited in cells treated with a human endogenous acid cysteine proteinase inhibitor.


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