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J. Virol., Nov 1997, 8221-8229, Vol 71, No. 11
Copyright © 1997, American Society for Microbiology

Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins

TJ Wickham, E Tzeng, LL Shears 2nd, PW Roelvink, Y Li, GM Lee, DE Brough, A Lizonova and I Kovesdi
GenVec, Inc., Rockville, Maryland 20852, USA.

Alteration of the natural tropism of adenovirus (Ad) will permit gene transfer into specific cell types and thereby greatly broaden the scope of target diseases that can be treated by using Ad. We have constructed two Ad vectors which contain modifications to the Ad fiber coat protein that redirect virus binding to either alpha(v) integrin [AdZ.F(RGD)] or heparan sulfate [AdZ.F(pK7)] cellular receptors. These vectors were constructed by a novel method involving E4 rescue of an E4-deficient Ad with a transfer vector containing both the E4 region and the modified fiber gene. AdZ.F(RGD) increased gene delivery to endothelial and smooth muscle cells expressing alpha(v) integrins. Likewise, AdZ.F(pK7) increased transduction 5- to 500-fold in multiple cell types lacking high levels of Ad fiber receptor, including macrophage, endothelial, smooth muscle, fibroblast, and T cells. In addition, AdZ.F(pK7) significantly increased gene transfer in vivo to vascular smooth muscle cells of the porcine iliac artery following balloon angioplasty. These vectors may therefore be useful in gene therapy for vascular restenosis or for targeting endothelial cells in tumors. Although binding to the fiber receptor still occurs with these vectors, they demonstrate the feasibility of tissue-specific receptor targeting in cells which express low levels of Ad fiber receptor.

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• Ring, C. J. A. (2002). Cytolytic viruses as potential anti-cancer agents. J. Gen. Virol. 83: 491-502 [Abstract] [Full Text]  
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• Schmidt, U., Rudolph, R., Bohm, G. (2001). Binding of external ligands onto an engineered virus capsid. Protein Eng Des Sel 14: 769-774 [Abstract] [Full Text]  
• Magnusson, M. K., Hong, S. S., Boulanger, P., Lindholm, L. (2001). Genetic Retargeting of Adenovirus: Novel Strategy Employing ""Deknobbing"" of the Fiber. J. Virol. 75: 7280-7289 [Abstract] [Full Text]  
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• YOUNG, L S, MAUTNER, V (2001). The promise and potential hazards of adenovirus gene therapy. Gut 48: 733-736 [Full Text]  
• Havenga, M. J. E., Lemckert, A. A. C., Grimbergen, J. M., Vogels, R., Huisman, L. G. M., Valerio, D., Bout, A., Quax, P. H. A. (2001). Improved Adenovirus Vectors for Infection of Cardiovascular Tissues. J. Virol. 75: 3335-3342 [Abstract] [Full Text]  
• Cripe, T. P., Dunphy, E. J., Holub, A. D., Saini, A., Vasi, N. H., Mahller, Y. Y., Collins, M. H., Snyder, J. D., Krasnykh, V., Curiel, D. T., Wickham, T. J., DeGregori, J., Bergelson, J. M., Currier, M. A. (2001). Fiber Knob Modifications Overcome Low, Heterogeneous Expression of the Coxsackievirus-Adenovirus Receptor That Limits Adenovirus Gene Transfer and Oncolysis for Human Rhabdomyosarcoma Cells. Cancer Res. 61: 2953-2960 [Abstract] [Full Text]  
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• Ebbinghaus, C., Al-Jaibaji, A., Operschall, E., Schöffel, A., Peter, I., Greber, U. F., Hemmi, S. (2001). Functional and Selective Targeting of Adenovirus to High-Affinity Fc{gamma} Receptor I-Positive Cells by Using a Bispecific Hybrid Adapter. J. Virol. 75: 480-489 [Abstract] [Full Text]  
• Suzuki, K., Fueyo, J., Krasnykh, V., Reynolds, P. N., Curiel, D. T., Alemany, R. (2001). A Conditionally Replicative Adenovirus with Enhanced Infectivity Shows Improved Oncolytic Potency. Clin. Cancer Res. 7: 120-126 [Abstract] [Full Text]  
• Xia, H., Anderson, B., Mao, Q., Davidson, B. L. (2000). Recombinant Human Adenovirus: Targeting to the Human Transferrin Receptor Improves Gene Transfer to Brain Microcapillary Endothelium. J. Virol. 74: 11359-11366 [Abstract] [Full Text]  
• Gu, J., Kagawa, S., Takakura, M., Kyo, S., Inoue, M., Roth, J. A., Fang, B. (2000). Tumor-specific Transgene Expression from the Human Telomerase Reverse Transcriptase Promoter Enables Targeting of the Therapeutic Effects of the Bax Gene to Cancers. Cancer Res. 60: 5359-5364 [Abstract] [Full Text]  
• Dmitriev, I., Kashentseva, E., Rogers, B. E., Krasnykh, V., Curiel, D. T. (2000). Ectodomain of Coxsackievirus and Adenovirus Receptor Genetically Fused to Epidermal Growth Factor Mediates Adenovirus Targeting to Epidermal Growth Factor Receptor-Positive Cells. J. Virol. 74: 6875-6884 [Abstract] [Full Text]  
• Nicklin, S. A., White, S. J., Watkins, S. J., Hawkins, R. E., Baker, A. H. (2000). Selective Targeting of Gene Transfer to Vascular Endothelial Cells by Use of Peptides Isolated by Phage Display. Circulation 102: 231-237 [Abstract] [Full Text]  
• Pickles, R. J., Fahrner, J. A., Petrella, J. M., Boucher, R. C., Bergelson, J. M. (2000). Retargeting the Coxsackievirus and Adenovirus Receptor to the Apical Surface of Polarized Epithelial Cells Reveals the Glycocalyx as a Barrier to Adenovirus-Mediated Gene Transfer. J. Virol. 74: 6050-6057 [Abstract] [Full Text]  
• Boland, A., Ricard, M., Opolon, P., Bidart, J.-M., Yeh, P., Filetti, S., Schlumberger, M., Perricaudet, M. (2000). Adenovirus-mediated Transfer of the Thyroid Sodium/Iodide Symporter Gene into Tumors for a Targeted Radiotherapy. Cancer Res. 60: 3484-3492 [Abstract] [Full Text]  
• Batra, R. K., Dubinett, S. M., Henkle, B. W., Sharma, S., Gardner, B. K. (2000). Adenoviral Gene Transfer Is Inhibited by Soluble Factors in Malignant Pleural Effusions. Am. J. Respir. Cell Mol. Bio. 22: 613-619 [Abstract] [Full Text]  
• Rebel, V. I., Hartnett, S., Denham, J., Chan, M., Finberg, R., Sieff, C. A. (2000). Maturation and Lineage-Specific Expression of the Coxsackie and Adenovirus Receptor in Hematopoietic Cells. Stem Cells 18: 176-182 [Abstract] [Full Text]  
• Li, S., Tan, Y., Viroonchatapan, E., Pitt, B. R., Huang, L. (2000). Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L504-L511 [Abstract] [Full Text]  
• Sandig, V., Youil, R., Bett, A. J., Franlin, L. L., Oshima, M., Maione, D., Wang, F., Metzker, M. L., Savino, R., Caskey, C. T. (2000). Optimization of the helper-dependent adenovirus system for production and potency in vivo. Proc. Natl. Acad. Sci. USA 97: 1002-1007 [Abstract] [Full Text]  
• Kibbe, M. R., Murdock, A., Wickham, T., Lizonova, A., Kovesdi, I., Nie, S., Shears, L., Billiar, T. R., Tzeng, E. (2000). Optimizing Cardiovascular Gene Therapy: Increased Vascular Gene Transfer With Modified Adenoviral Vectors. Arch Surg 135: 191-197 [Abstract] [Full Text]  
• Von Seggern, D. J., Huang, S., Fleck, S. K., Stevenson, S. C., Nemerow, G. R. (2000). Adenovirus Vector Pseudotyping in Fiber-Expressing Cell Lines: Improved Transduction of Epstein-Barr Virus-Transformed B Cells. J. Virol. 74: 354-362 [Abstract] [Full Text]  
• Brenner, M. (1999). Gene Transfer by Adenovectors. Blood 94: 3965-3967 [Full Text]  
• Pearson, A. S., Koch, P. E., Atkinson, N., Xiong, M., Finberg, R. W., Roth, J. A., Fang, B. (1999). Factors Limiting Adenovirus-mediated Gene Transfer into Human Lung and Pancreatic Cancer Cell Lines. Clin. Cancer Res. 5: 4208-4213 [Abstract] [Full Text]  
• Einfeld, D. A., Brough, D. E., Roelvink, P. W., Kovesdi, I., Wickham, T. J. (1999). Construction of a Pseudoreceptor That Mediates Transduction by Adenoviruses Expressing a Ligand in Fiber or Penton Base. J. Virol. 73: 9130-9136 [Abstract] [Full Text]  
• Kirby, I., Davison, E., Beavil, A. J., Soh, C. P. C., Wickham, T. J., Roelvink, P. W., Kovesdi, I., Sutton, B. J., Santis, G. (1999). Mutations in the DG Loop of Adenovirus Type 5 Fiber Knob Protein Abolish High-Affinity Binding to Its Cellular Receptor CAR. J. Virol. 73: 9508-9514 [Abstract] [Full Text]  
• Harvey, B.-G., Hackett, N. R., El-Sawy, T., Rosengart, T. K., Hirschowitz, E. A., Lieberman, M. D., Lesser, M. L., Crystal, R. G. (1999). Variability of Human Systemic Humoral Immune Responses to Adenovirus Gene Transfer Vectors Administered to Different Organs. J. Virol. 73: 6729-6742 [Abstract] [Full Text]  
• Miyazawa, N., Leopold, P. L., Hackett, N. R., Ferris, B., Worgall, S., Falck-Pedersen, E., Crystal, R. G. (1999). Fiber Swap between Adenovirus Subgroups B and C Alters Intracellular Trafficking of Adenovirus Gene Transfer Vectors. J. Virol. 73: 6056-6065 [Abstract] [Full Text]  
• Shinoura, N., Yoshida, Y., Tsunoda, R., Ohashi, M., Zhang, W., Asai, A., Kirino, T., Hamada, H. (1999). Highly Augmented Cytopathic Effect of a Fiber-mutant E1B-defective Adenovirus for Gene Therapy of Gliomas. Cancer Res. 59: 3411-3416 [Abstract] [Full Text]  
• Vigne, E., Mahfouz, I., Dedieu, J.-F., Brie, A., Perricaudet, M., Yeh, P. (1999). RGD Inclusion in the Hexon Monomer Provides Adenovirus Type 5-Based Vectors with a Fiber Knob-Independent Pathway for Infection. J. Virol. 73: 5156-5161 [Abstract] [Full Text]  
• Gu, D.-l., Gonzalez, A. M., Printz, M. A., Doukas, J., Ying, W., D'Andrea, M., Hoganson, D. K., Curiel, D. T., Douglas, J. T., Sosnowski, B. A., Baird, A., Aukerman, S. L., Pierce, G. F. (1999). Fibroblast Growth Factor 2 Retargeted Adenovirus Has Redirected Cellular Tropism: Evidence for Reduced Toxicity and Enhanced AntitumorActivity in Mice. Cancer Res. 59: 2608-2614 [Abstract] [Full Text]  
• Kaner, R. J., Worgall, S., Leopold, P. L., Stolze, E., Milano, E., Hidaka, C., Ramalingam, R., Hackett, N. R., Singh, R., Bergelson, J., Finberg, R., Falck-Pedersen, E., Crystal, R. G. (1999). Modification of the Genetic Program of Human Alveolar Macrophages by Adenovirus Vectors In Vitro Is Feasible but Inefficient, Limited in Part by the Low Level of Expression of the Coxsackie/Adenovirus Receptor. Am. J. Respir. Cell Mol. Bio. 20: 361-370 [Abstract] [Full Text]  
• Legrand, V., Spehner, D., Schlesinger, Y., Settelen, N., Pavirani, A., Mehtali, M. (1999). Fiberless Recombinant Adenoviruses: Virus Maturation and Infectivity in the Absence of Fiber. J. Virol. 73: 907-919 [Abstract] [Full Text]  
• Von Seggern, D. J., Chiu, C. Y., Fleck, S. K., Stewart, P. L., Nemerow, G. R. (1999). A Helper-Independent Adenovirus Vector with E1, E3, and Fiber Deleted: Structure and Infectivity of Fiberless Particles. J. Virol. 73: 1601-1608 [Abstract] [Full Text]  
• Laquerre, S., Anderson, D. B., Stolz, D. B., Glorioso, J. C. (1998). Recombinant Herpes Simplex Virus Type 1 Engineered for Targeted Binding to Erythropoietin Receptor-Bearing Cells. J. Virol. 72: 9683-9697 [Abstract] [Full Text]  
• Dmitriev, I., Krasnykh, V., Miller, C. R., Wang, M., Kashentseva, E., Mikheeva, G., Belousova, N., Curiel, D. T. (1998). An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism. J. Virol. 72: 9706-9713 [Abstract] [Full Text]  
• Leon, R. P., Hedlund, T., Meech, S. J., Li, S., Schaack, J., Hunger, S. P., Duke, R. C., DeGregori, J. (1998). Adenoviral-mediated gene transfer in lymphocytes. Proc. Natl. Acad. Sci. USA 95: 13159-13164 [Abstract] [Full Text]