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J. Virol., 08 1996, 5061-5066, Vol 70, No. 8
Copyright © 1996, American Society for Microbiology

Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein

S Bertagnoli, J Gelfi, G Le Gall, E Boilletot, JF Vautherot, D Rasschaert, S Laurent, F Petit, C Boucraut-Baralon and A Milon
Laboratoire Associe de Microbiologie Moleculaire, Institut National de la Recherche Agronomique and Ecole Nationale Veterinaire, Toulouse, France.

Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease. These recombinant viruses expressed the RHDV capsid protein (VP60). The recombinant protein, which is 60 kDa in size, was antigenic, as revealed by its reaction in immunoprecipitation with antibodies raised against RHDV. Both recombinant viruses induced high levels of RHDV- and myxoma virus-specific antibodies in rabbits after immunization. Inoculations by the intradermal route protected animals against virulent RHDV and myxoma virus challenges.


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Copyright © 1996 by the American Society for Microbiology. All rights reserved.