J. Virol., Aug 1996, 4914-4918, Vol 70, No. 8
Copyright © 1996, American Society for Microbiology

AP1 enhances polyomavirus DNA replication by promoting T-antigen- mediated unwinding of DNA

W Guo, WJ Tang, X Bu, V Bermudez, M Martin and WR Folk
Department of Biochemistry, University of Missouri--Columbia 65202, USA.

An early step in the initiation of polyomavirus DNA replication is viral large-T-antigen-mediated unwinding of the origin. We report that components of the AP1 transcription factor, Fos and Jun, interact with T antigen in vitro to enhance unwinding of the viral origin. This provides a biochemical basis for the capacity of AP1 to activate viral DNA replication in vivo.

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