This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gelder, C. M. Articles by Askonas, B. A. Search for Related Content PubMed PubMed Citation Articles by Gelder, C. M. Articles by Askonas, B. A.

 Previous Article  |  Next Article 

J. Virol., 07 1996, 4787-4790, Vol 70, No. 7
Copyright © 1996, American Society for Microbiology

Human CD4+ T-cell recognition of influenza A virus hemagglutinin after subunit vaccination

CM Gelder, JR Lamb and BA Askonas
Infection and Immunity Section, Department of Biology, Imperial College of Science, Technology and Medicine, London, United Kingdom.

We have examined human CD4+ T-cell recognition of influenza A/Beijing/32/92 (H3N2) virus hemagglutinin following influenza virus HANA subunit vaccination. CD4+ T-cell repertoires were dominated by recognition of epitopes located in conserved regions of the molecule, in a major histocompatibility complex class II haplotype-dependent manner, analogous to that observed following natural infection.

This article has been cited by other articles:

• Lunemann, J. D., Frey, O., Eidner, T., Baier, M., Roberts, S., Sashihara, J., Volkmer, R., Cohen, J. I., Hein, G., Kamradt, T., Munz, C. (2008). Increased Frequency of EBV-Specific Effector Memory CD8+ T Cells Correlates with Higher Viral Load in Rheumatoid Arthritis. J. Immunol. 181: 991-1000 [Abstract] [Full Text]  
• Wang, X.-F., Kerzerho, J., Adotevi, O., Nuyttens, H., Badoual, C., Munier, G., Oudard, S., Tu, S., Tartour, E., Maillere, B. (2008). Comprehensive Analysis of HLA-DR- and HLA-DP4-Restricted CD4+ T Cell Response Specific for the Tumor-Shared Antigen Survivin in Healthy Donors and Cancer Patients. J. Immunol. 181: 431-439 [Abstract] [Full Text]  
• Landry, S. J. (2008). Three-Dimensional Structure Determines the Pattern of CD4+ T-Cell Epitope Dominance in Influenza Virus Hemagglutinin. J. Virol. 82: 1238-1248 [Abstract] [Full Text]  
• Richards, K. A., Chaves, F. A., Krafcik, F. R., Topham, D. J., Lazarski, C. A., Sant, A. J. (2007). Direct Ex Vivo Analyses of HLA-DR1 Transgenic Mice Reveal an Exceptionally Broad Pattern of Immunodominance in the Primary HLA-DR1-Restricted CD4 T-Cell Response to Influenza Virus Hemagglutinin. J. Virol. 81: 7608-7619 [Abstract] [Full Text]  
• Lunemann, J. D., Edwards, N., Muraro, P. A., Hayashi, S., Cohen, J. I., Munz, C., Martin, R. (2006). Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis. Brain 129: 1493-1506 [Abstract] [Full Text]  
• Yeung, V. P., Chang, J., Miller, J., Barnett, C., Stickler, M., Harding, F. A. (2004). Elimination of an Immunodominant CD4+ T Cell Epitope in Human IFN-{beta} Does Not Result in an In Vivo Response Directed at the Subdominant Epitope. J. Immunol. 172: 6658-6665 [Abstract] [Full Text]  
• Bielekova, B., Sung, M.-H., Kadom, N., Simon, R., McFarland, H., Martin, R. (2004). Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis. J. Immunol. 172: 3893-3904 [Abstract] [Full Text]  
• Holz, A., Bielekova, B., Martin, R., Oldstone, M. B. A. (2000). Myelin-Associated Oligodendrocytic Basic Protein: Identification of an Encephalitogenic Epitope and Association with Multiple Sclerosis. J. Immunol. 164: 1103-1109 [Abstract] [Full Text]  
• Bielekova, B., Lincoln, A., McFarland, H., Martin, R. (2000). Therapeutic Potential of Phosphodiesterase-4 and -3 Inhibitors in Th1-Mediated Autoimmune Diseases. J. Immunol. 164: 1117-1124 [Abstract] [Full Text]