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J. Virol., Jun 1996, 4146-4149, Vol 70, No. 6
Copyright © 1996, American Society for Microbiology

Maintenance of pluripotency in mouse embryonic stem cells persistently infected with murine coronavirus

A Okumura, K Machii, S Azuma, Y Toyoda and S Kyuwa
Department of Animal Pathology, Institute of Medical Science, University of Tokyo, Japan.

A persistently coronavirus-infected embryonic stem (ES) cell line A3/MHV was established by infecting an ES cell line, A3-1, with mouse hepatitis virus type-2. Although almost all A3/MHV cells were found infected, both A3/MHV and A3-1 cells expressed comparable levels of cell surface differentiation markers. In addition, A3/MHV cells retained the ability to form embryoid bodies. These results suggest that persistent coronavirus infection does not affect the differentiation of ES cells.

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