Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription

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J. Virol., 06 1996, 3551-3560, Vol 70, No. 6
Copyright © 1996, American Society for Microbiology

Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription

D Braaten, EK Franke and J Luban
Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York 10032, USA.

Cyclophilin A (CyPA) is incorporated into human immunodeficiency virus type 1 (HIV-1) virions via contact with the Gag polyprotein. Genetic or pharmacologic disruption of CyPA incorporation causes a quantitative reduction in virion infectivity with no discernible effects on virion assembly or on endogenous reverse transcriptase activity. Instead, the reduction of virion-associated CyPA is accompanied by a parallel, quantitative decrease in the initiation of viral DNA synthesis after infection of T cells. The infectivity of CyPA-deficient virions is not restored by pseudotyping with Env of amphotropic murine leukemia virus, demonstrating that CyPA is not required for the HIV-1-Env-CD4 interaction. These results indicate that CyPA is required for an early step in the HIV-1 life cycle following receptor binding and membrane fusion but preceding reverse transcription. CyPA is the first cellular protein other than the cell surface receptor shown to be required for an early event in the life cycle of a retrovirus.

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Hatziioannou, T., Goff, S. P. (2001). Infection of Nondividing Cells by Rous Sarcoma Virus. J. Virol. 75: 9526-9531 [Abstract] [Full Text]
Dietrich, L., Ehrlich, L. S., LaGrassa, T. J., Ebbets-Reed, D., Carter, C. (2001). Structural Consequences of Cyclophilin A Binding on Maturational Refolding in Human Immunodeficiency Virus Type 1 Capsid Protein. J. Virol. 75: 4721-4733 [Abstract] [Full Text]
Barrasa, M. I., Guo, J.-T., Saputelli, J., Mason, W. S., Seeger, C. (2001). Does a cdc2 Kinase-Like Recognition Motif on the Core Protein of Hepadnaviruses Regulate Assembly and Disintegration of Capsids?. J. Virol. 75: 2024-2028 [Abstract] [Full Text]
Cairns, T. M., Craven, R. C. (2001). Viral DNA Synthesis Defects in Assembly-Competent Rous Sarcoma Virus CA Mutants. J. Virol. 75: 242-250 [Abstract] [Full Text]
Bieniasz, P. D., Cullen, B. R. (2000). Multiple Blocks to Human Immunodeficiency Virus Type 1 Replication in Rodent Cells. J. Virol. 74: 9868-9877 [Abstract] [Full Text]
Cimarelli, A., Sandin, S., Höglund, S., Luban, J. (2000). Rescue of Multiple Viral Functions by a Second-Site Suppressor of a Human Immunodeficiency Virus Type 1 Nucleocapsid Mutation. J. Virol. 74: 4273-4283 [Abstract] [Full Text]
Cimarelli, A., Sandin, S., Höglund, S., Luban, J. (2000). Basic Residues in Human Immunodeficiency Virus Type 1 Nucleocapsid Promote Virion Assembly via Interaction with RNA. J. Virol. 74: 3046-3057 [Abstract] [Full Text]
Laurent, L. C., Olsen, M. N., Crowley, R. A., Savilahti, H., Brown, P. O. (2000). Functional Characterization of the Human Immunodeficiency Virus Type 1 Genome by Genetic Footprinting. J. Virol. 74: 2760-2769 [Abstract] [Full Text]
Burniston, M. T., Cimarelli, A., Colgan, J., Curtis, S. P., Luban, J. (1999). Human Immunodeficiency Virus Type 1 Gag Polyprotein Multimerization Requires the Nucleocapsid Domain and RNA and Is Promoted by the Capsid-Dimer Interface and the Basic Region of Matrix Protein. J. Virol. 73: 8527-8540 [Abstract] [Full Text]
Cimarelli, A., Luban, J. (1999). Translation Elongation Factor 1-Alpha Interacts Specifically with the Human Immunodeficiency Virus Type 1�Gag Polyprotein. J. Virol. 73: 5388-5401 [Abstract] [Full Text]
Zhao, J., Hyman, L., Moore, C. (1999). Formation of mRNA 3' Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis. Microbiol. Mol. Biol. Rev. 63: 405-445 [Abstract] [Full Text]
Gao, G., Goff, S. P. (1999). Somatic Cell Mutants Resistant to Retrovirus Replication: Intracellular Blocks during the Early Stages of Infection. Mol. Biol. Cell 10: 1705-1717 [Abstract] [Full Text]
Srivastava, M., Cartas, M., Rizvi, T. A., Singh, S. P., Serio, D., Kalyanaraman, V. S., Pollard, H. B., Srinivasan, A. (1999). HIV-1 Gag shares a signature motif with annexin (Anx7), which is required for virus replication. Proc. Natl. Acad. Sci. USA 96: 2704-2709 [Abstract] [Full Text]
Wu, X., Liu, H., Xiao, H., Conway, J. A., Hehl, E., Kalpana, G. V., Prasad, V., Kappes, J. C. (1999). Human Immunodeficiency Virus Type 1�Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription Complex. J. Virol. 73: 2126-2135 [Abstract] [Full Text]
Endrich, M. M., Gehrig, P., Gehring, H. (1999). Maturation-induced Conformational Changes of HIV-1 Capsid Protein and Identification of Two High Affinity Sites for Cyclophilins in the C-terminal Domain. J. Biol. Chem. 274: 5326-5332 [Abstract] [Full Text]
Dettenhofer, M., Yu, X.-F. (1999). Highly Purified Human Immunodeficiency Virus Type 1�Reveals a Virtual Absence of Vif in Virions. J. Virol. 73: 1460-1467 [Abstract] [Full Text]
Hani, J., Schelbert, B., Bernhardt, A., Domdey, H., Fischer, G., Wiebauer, K., Rahfeld, J.-U. (1999). Mutations in a Peptidylprolyl-cis/trans-isomerase Gene Lead to a Defect in 3'-End Formation of a Pre-mRNA in Saccharomyces cerevisiae. J. Biol. Chem. 274: 108-116 [Abstract] [Full Text]
de Haard, H. J.�W., Kazemier, B., Koolen, M. J.�M., Nijholt, L. J., Meloen, R. H., van Gemen, B., Hoogenboom, H. R., Arends, J.-W. (1998). Selection of Recombinant, Library-Derived Antibody Fragments against p24 for Human Immunodeficiency Virus Type 1�Diagnostics. CVI 5: 636-644 [Abstract] [Full Text]
Yin, L., Braaten, D., Luban, J. (1998). Human Immunodeficiency Virus Type 1�Replication Is Modulated by Host Cyclophilin A Expression Levels. J. Virol. 72: 6430-6436 [Abstract] [Full Text]
Emerman, M., Malim, M. H. (1998). HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology. Science 280: 1880-1884 [Abstract] [Full Text]
Gross, I., Hohenberg, H., Huckhagel, C., Krausslich, H.-G. (1998). N-Terminal Extension of Human Immunodeficiency Virus Capsid Protein Converts the In Vitro Assembly Phenotype from Tubular to Spherical Particles. J. Virol. 72: 4798-4810 [Abstract] [Full Text]
Callahan, M. A., Handley, M. A., Lee, Y.-H., Talbot, K. J., Harper, J. W., Panganiban, A. T. (1998). Functional Interaction of Human Immunodeficiency Virus Type 1�Vpu and Gag with a Novel Member of the Tetratricopeptide Repeat Protein Family. J. Virol. 72: 5189-5197 [Abstract] [Full Text]
Kiernan, R. E., Ono, A., Englund, G., Freed, E. O. (1998). Role of Matrix in an Early Postentry Step in the Human Immunodeficiency Virus Type 1�Life Cycle. J. Virol. 72: 4116-4126 [Abstract] [Full Text]
Kong, L. B., An, D., Ackerson, B., Canon, J., Rey, O., Chen, I. S.�Y., Krogstad, P., Stewart, P. L. (1998). Cryoelectron Microscopic Examination of Human Immunodeficiency Virus Type 1�Virions with Mutations in the Cyclophilin A Binding Loop. J. Virol. 72: 4403-4407 [Abstract] [Full Text]
Tanchou, V., Decimo, D., Pechoux, C., Lener, D., Rogemond, V., Berthoux, L., Ottmann, M., Darlix, J.-L. (1998). Role of the N-Terminal Zinc Finger of Human Immunodeficiency Virus Type 1�Nucleocapsid Protein in Virus Structure and Replication. J. Virol. 72: 4442-4447 [Abstract] [Full Text]
Sherry, B., Zybarth, G., Alfano, M., Dubrovsky, L., Mitchell, R., Rich, D., Ulrich, P., Bucala, R., Cerami, A., Bukrinsky, M. (1998). Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes. Proc. Natl. Acad. Sci. USA 95: 1758-1763 [Abstract] [Full Text]
Damaso, C., Moussatche, N (1998). Inhibition of vaccinia virus replication by cyclosporin A analogues correlates with their affinity for cellular cyclophilins. J. Gen. Virol. 79: 339-346 [Abstract]
Ackerson, B., Rey, O., Canon, J., Krogstad, P. (1998). Cells with High Cyclophilin A Content Support Replication of Human Immunodeficiency Virus Type 1�Gag Mutants with Decreased Ability To Incorporate Cyclophilin A. J. Virol. 72: 303-308 [Abstract] [Full Text]
Dolinski, K., Scholz, C., Muir, R. S., Rospert, S., Schmid, F. X., Cardenas, M. E., Heitman, J. (1997). Functions of FKBP12 and Mitochondrial Cyclophilin Active Site Residues In Vitro and In Vivo in Saccharomyces cerevisiae. Mol. Biol. Cell 8: 2267-2280 [Abstract] [Full Text]
Bukovsky, A. A., Weimann, A., Accola, M. A., Gottlinger, H. G. (1997). Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence. Proc. Natl. Acad. Sci. USA 94: 10943-10948 [Abstract] [Full Text]
Vance, J. E., LeBlanc, D. A., Wingfield, P., London, R. E. (1997). Conformational Selectivity of HIV-1 Protease Cleavage of X-Pro Peptide Bonds and Its Implications. J. Biol. Chem. 272: 15603-15606 [Abstract] [Full Text]
Bosco, D. A., Eisenmesser, E. Z., Pochapsky, S., Sundquist, W. I., Kern, D. (2002). Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proc. Natl. Acad. Sci. USA 99: 5247-5252 [Abstract] [Full Text]
Pushkarsky, T., Zybarth, G., Dubrovsky, L., Yurchenko, V., Tang, H., Guo, H., Toole, B., Sherry, B., Bukrinsky, M. (2001). CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. Proc. Natl. Acad. Sci. USA 98: 6360-6365 [Abstract] [Full Text]

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