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J. Virol., 03 1996, 1521-1526, Vol 70, No. 3
O Utermohlen, A Dangel, A Tarnok and F Lehmann-Grube
Mice were infected with lymphocytic choriomeningitis virus and injected
once 24 h later with a monoclonal antibody directed against gamma
interferon. In comparison with controls, the increase of numbers of CD8+ T
cells and the generation of virus-specific cytotoxic T lymphocytes in
spleens and virus clearance from organs were diminished, as was the ability
of spleen cells to transmit adoptive immunity to infected recipients. The
same treatment slightly but consistently lessened rather than augmented the
virus titers early in infection, which was also observed in thymusless
nu/nu mice. Injection into infected mice of the lymphokine itself in
quantities probably higher than are produced endogenously resulted in lower
virus titers in spleens but higher titers in livers. The adoptive immunity
in infected mice achieved by infusion of immune spleen cells was not
altered by treating the recipients with gamma interferon monoclonal
antibody. Such treatment did not measurably affect the production of
antiviral serum antibodies. We conclude that in lymphocytic
choriomeningitis virus- infected mice, gamma interferon is needed for the
generation of antivirally active CD8+ T lymphocytes, and furthermore that
in this experimental model, direct antiviral effects of the lymphokine
elude detection.
Copyright © 1996, American Society for Microbiology
Modulation by gamma interferon of antiviral cell-mediated immune responses in vivo
Heinrich-Pette-Institut fur Experimentelle Virologie und Immunologie, Universitat Hamburg, Germany.
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