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J. Virol., 01 1996, 217-222, Vol 70, No. 1
Copyright © 1996, American Society for Microbiology

Foamy virus vectors

DW Russell and AD Miller
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.

Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.

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