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J Virol. 1971 June; 7(6): 821-829
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Inhibition of Poxvirus Maturation by Rifamycin Derivatives and Related Compounds

Department of Virology and M.R.C. Virology Unit, Institute of Virology, University of Glasgow, Glasgow, Scotland

ABSTRACT

The effect of a number of rifamycin derivatives and related compounds on the reversibility of the rifampin-induced virus maturation block was studied by using BHK-21 cells infected with vaccinia virus. All of the derivatives of 3-formyl rifamycin SV maintained this block, the required concentration varying from 100 to 1,000 µg/ml. These compounds vary only in the nature of the side-chain attached to the 3C atom on the naphthohydroquinone moiety; no obvious correlation between the nature of this side-chain and antiviral activity was found. Streptovaricin complex and tolypomycin R also maintained the maturation block; tolypomycin also produced marked alterations in the appearance of the viroplasm contained in rifampin-induced inclusions and immature virus particles.

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