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Synergistic Effect of Herpes Simplex Virus and Cytosine Arabinoside on Human Chromosomes

¹ Department of Microbiology, College of Medicine, The Milton S. Hershey Medical Center of The Pennsylvania State University, Hershey, Pennsylvania 17033

ABSTRACT

The combined treatment of cultures of human embryonic lung cells with herpes simplex virus type 2 and cytosine arabinoside produced a significantly increased number of cells containing multiple chromatid and chromosome breaks. The incidence of such cells was found to be approximately two and one half times greater than the additive effects of virus and cytosine arabinoside induced separately and is therefore synergistic.

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• Wigdahl, B., Scheck, A., De Clercq, E, Rapp, F (1982). High efficiency latency and activation of herpes simplex virus in human cells. Science 217: 1145-1146 [Abstract]