This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vilaginès, R. Articles by McAuslan, B. R. Search for Related Content PubMed PubMed Citation Articles by Vilaginès, R. Articles by McAuslan, B. R.

Proteins of Polyhedral Cytoplasmic Deoxyvirus II. Nucleotide Phosphohydrolase Activity Associated with Frog Virus 3

^a Roche Institute of Molecular Biology, Nutley, New Jersey 07110

ABSTRACT

A nucleotide phosphohydrolase is firmly associated with a purified polyhedral cytoplasmic deoxyvirus, frog virus 3. This adenosine triphosphatase is distinguishable from known mammalian cell adenosine triphosphatases and from adenosine triphosphatase of an unrelated cytoplasmic replicating virus grown in the same host cell. The enzyme activity has a high specificity for adenosine triphosphate; the product of the reaction is adenosine diphosphate. The presence of similar activities in reovirus and poxvirus indicates that adenosine triphosphatase might have a function in the replication of these viruses.

¹ Roche Institute postdoctoral fellow, on leave from the Pasteur Institute.