This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hinze, H. C. Articles by Walker, D. L. Search for Related Content PubMed PubMed Citation Articles by Hinze, H. C. Articles by Walker, D. L.

Comparison of Cytocidal and Noncytocidal Strains of Shope Rabbit Fibroma Virus

Department of Medical Microbiology, University of Wisconsin Medical School, Madison, Wisconsin 53706

ABSTRACT

Seven strains of Shope fibroma virus were compared for their effect on rabbit cells in vitro. All but one of the naturally occurring strains examined in this study produced a similar response in the infected cultures. This consisted of continued cell multiplication together with changes in cell morphology and growth pattern. In contrast, a recently isolated strain of fibroma virus, the M1 strain, was found to produce a gradual cell destruction under the same cultural conditions. A comparison of the cytocidal M1 strain with a representative noncytocidal strain in vitro showed no differences in the rate of multiplication, plaque type, antigenic composition, or heat lability. Only minor differences were found in the tumors produced in rabbits by these strains.