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J Virol. 1971 April; 7(4): 531-533
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Identity of Genes Coding for Soluble and Structural Dihydrofolate Reductases in Bacteriophage T4

Christopher K. Mathews

Department of Biochemistry, University of Arizona, College of Medicine, Tucson, Arizona 85724

ABSTRACT

By recombination between bacteriophage T4 wh2, a dihydrofolate reductaseless mutant, and T6, I have prepared T4 whT6, a T4 strain which codes for the T6-specific soluble dihydrofolate reductase. This strain has the heat sensitivity of T6, not T4, which provides direct evidence that the wh gene codes for both the soluble dihydrofolate reductase and the structural dihydrofolate reductase which is a constituent of T-even phage tail plates.

J Virol. 1971 April; 7(4): 531-533
Copyright © 1971 American Society for Microbiology. All Rights Reserved.





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J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
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Copyright © 1971 by the American Society for Microbiology. All rights reserved.