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J Virol. 1971 April; 7(4): 491-498
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Replication and Recombination in Ligase-Deficient rII Bacteriophage T4D

H. M. Krisch, D. B. Shah and Hillard Berger

1 Departments of Biophysics and Biology, The Johns Hopkins University, Baltimore, Maryland 21218

ABSTRACT

Deoxyribonucleic acid replication and genetic recombination were investigated after infection of Escherichia coli with ligase-deficient rII bacteriophage T4D. The major observations are: (i) deoxyribonucleic acid synthesis is discontinuous, (ii) the discontinuities are more slowly repaired than in wild-type infection, (iii) host ligase is required for viability, and (iv) genetic recombination is increased.

J Virol. 1971 April; 7(4): 491-498
Copyright © 1971 American Society for Microbiology. All Rights Reserved.



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Copyright © 1971 by the American Society for Microbiology. All rights reserved.