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Complete Transcription by the Transcriptase of Vesicular Stomatitis Virus

¹ Institute of Cancer Research, College of Physicians and Surgeons of Columbia University, New York, New York 10032

ABSTRACT

Vesicular stomatitis virus (VSV) transcriptase completely transcribes the VSV genome into messenger-size ribonucleic acid (RNA) species. The replicating complexes of template and product RNA, generated in vitro by VSV transcriptase, exhibit a mass parity between product and template molecules. Purified product RNA, after annealing to small amounts of viral RNA, rendered 92% of the viral RNA ribonuclease-resistant. It is calculated that, under optimal conditions, 60 min is required before the VSV genome is completely transcribed.

This article has been cited by other articles:

• Marcus, P. I., Engelhardt, D. L., Hunt, J. M., Sekellick, M. J. (1971). Interferon Action: Inhibition of Vesicular Stomatitis Virus RNA Synthesis Induced by Virion-Bound Polymerase. Science 174: 593-598 [Abstract]