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Absence of Interference During High-Multiplicity Infection by Clonally Purified Vesicular Stomatitis Virus

^a Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

ABSTRACT

Stocks of vesicular stomatitis virus free of defective interfering particles were produced by serial clonal isolation. High-multiplicity infections with these stocks led to no interference or formation of defective interfering particles. Defective interfering particles were generated by three successive passages at high multiplicity.

¹ Present address: Channing Laboratory, Boston City Hospital, Boston, Mass. 02118.

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