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J. Virol., Sep 1995, 5821-5823, Vol 69, No. 9
Copyright © 1995, American Society for Microbiology

Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody

EK Franke, BX Chen, I Tatsis, A Diamanduros, BF Erlanger and J Luban
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

Human immunodeficiency virus type 1 is unique among retroviruses in that infectivity requires specific incorporation into virions of the cellular protein cyclophilin A through interactions with the Gag polyprotein. Here we show that monoclonal antibody B11 1.4, which recognizes a cyclophilin-binding epitope on cyclosporine, detects denatured or native human immunodeficiency virus type 1 capsid. B11 1.4 does not recognize the capsids of other retroviruses, and binding is inhibited by cyclosporine or by cyclophilin A.




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