This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Barr, M. C. Articles by Avery, R. J. Search for Related Content PubMed PubMed Citation Articles by Barr, M. C. Articles by Avery, R. J.

 Previous Article  |  Next Article 

J. Virol., Nov 1995, 7371-7374, Vol 69, No. 11
Copyright © 1995, American Society for Microbiology

Isolation of a highly cytopathic lentivirus from a nondomestic cat

MC Barr, L Zou, DL Holzschu, L Phillips, FW Scott, JW Casey and RJ Avery
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.

A feline immunodeficiency virus-like virus (FIV-Oma) isolated from a Pallas' cat (Otocolobus manul) is highly cytopathic in CrFK cells, in contrast to the chronic, noncytolytic infection established by an FIV isolate from a domestic cat (FIV-Fca). The virions have typical lentivirus morphology, density, and magnesium-dependent reverse transcriptase activity. The major core protein is antigenically cross- reactive with that of FIV-Fca; however, FIV-Oma transcripts do not cross-hybridize with FIV-Fca. A conserved region of the FIV-Oma pol gene has 76 to 80% nucleic acid identify with the corresponding pol regions of other feline lentiviruses and 64 to 69% identity with those of human, ovine, and equine lentiviruses.

This article has been cited by other articles:

• VandeWoude, S., Apetrei, C. (2006). Going Wild: Lessons from Naturally Occurring T-Lymphotropic Lentiviruses. Clin. Microbiol. Rev. 19: 728-762 [Abstract] [Full Text]  
• Brown, M., Lappin, M. R., Brown, J. L., Munkhtsog, B., Swanson, W. F. (2005). EXPLORING THE ECOLOGIC BASIS FOR EXTREME SUSCEPTIBILITY OF PALLAS' CATS (OTOCOLOBUS MANUL) TO FATAL TOXOPLASMOSIS. J Wildl Dis 41: 691-700 [Abstract] [Full Text]  
• TerWee, J. A., Yactor, J. K., Sondgeroth, K. S., VandeWoude, S. (2005). Puma Lentivirus Is Controlled in Domestic Cats after Mucosal Exposure in the Absence of Conventional Indicators of Immunity. J. Virol. 79: 2797-2806 [Abstract] [Full Text]  
• Biek, R., Rodrigo, A. G., Holley, D., Drummond, A., Anderson, C. R. Jr., Ross, H. A., Poss, M. (2003). Epidemiology, Genetic Diversity, and Evolution of Endemic Feline Immunodeficiency Virus in a Population of Wild Cougars. J. Virol. 77: 9578-9589 [Abstract] [Full Text]  
• Whitwam, T., Peretz, M., Poeschla, E. (2001). Identification of a Central DNA Flap in Feline Immunodeficiency Virus. J. Virol. 75: 9407-9414 [Abstract] [Full Text]  
• Matteucci, D., Poli, A., Mazzetti, P., Sozzi, S., Bonci, F., Isola, P., Zaccaro, L., Giannecchini, S., Calandrella, M., Pistello, M., Specter, S., Bendinelli, M. (2000). Immunogenicity of an Anti-Clade B Feline Immunodeficiency Fixed-Cell Virus Vaccine in Field Cats. J. Virol. 74: 10911-10919 [Abstract] [Full Text]  
• Nishimura, Y., Goto, Y., Yoneda, K., Endo, Y., Mizuno, T., Hamachi, M., Maruyama, H., Kinoshita, H., Koga, S., Komori, M., Fushuku, S., Ushinohama, K., Akuzawa, M., Watari, T., Hasegawa, A., Tsujimoto, H. (1999). Interspecies Transmission of Feline Immunodeficiency Virus from the Domestic Cat to the Tsushima Cat (Felis bengalensis euptilura) in the Wild. J. Virol. 73: 7916-7921 [Abstract] [Full Text]  
• Poeschla, E. M., Looney, D. J. (1998). CXCR4 Is Required by a Nonprimate Lentivirus: Heterologous Expression of Feline Immunodeficiency Virus in Human, Rodent, and Feline Cells. J. Virol. 72: 6858-6866 [Abstract] [Full Text]