This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Babic, N Articles by Ugolini, G Search for Related Content PubMed PubMed Citation Articles by Babic, N Articles by Ugolini, G

 Previous Article  |  Next Article 

J Virol. 1993 July; 67(7): 4421-4426

Role of essential glycoproteins gII and gp50 in transneuronal transfer of pseudorabies virus from the hypoglossal nerves of mice.

Laboratoire de Génétique des Virus, Centre National de la Recherche Scientifique, Gif-Sur-Yvette, France.

ABSTRACT

The propagation of pseudorabies virus (PrV) mutants deficient in essential glycoproteins gp50 and gII was studied after inoculation of transcomplemented gp50- and gII- PrV into the motor hypoglossal (XII) nerves of mice. In this model, viral spread from the infected XII motoneurons involves specific transneuronal transfer to connected cells and local, nonspecific transfer. For comparison, a PrV mutant lacking the nonessential nonstructural glycoprotein gX was included. Although the efficiencies of first-cycle replication were similar for the three viruses, only gX- and gp50- progeny mutants could spread from XII motoneurons via transneuronal and local transfer. The extents of transfer of gX- and gp50- PrV were comparable. The results show that the absence of gp50 does not alter the pattern of transneuronal or local spread of PrV, whereas gII is essential for both processes.

This article has been cited by other articles:

• Ch'ng, T. H., Spear, P. G., Struyf, F., Enquist, L. W. (2007). Glycoprotein D-Independent Spread of Pseudorabies Virus Infection in Cultured Peripheral Nervous System Neurons in a Compartmented System. J. Virol. 81: 10742-10757 [Abstract] [Full Text]  
• Feierbach, B., Bisher, M., Goodhouse, J., Enquist, L. W. (2007). In Vitro Analysis of Transneuronal Spread of an Alphaherpesvirus Infection in Peripheral Nervous System Neurons. J. Virol. 81: 6846-6857 [Abstract] [Full Text]  
• Klopfleisch, R., Klupp, B. G., Fuchs, W., Kopp, M., Teifke, J. P., Mettenleiter, T. C. (2006). Influence of pseudorabies virus proteins on neuroinvasion and neurovirulence in mice.. J. Virol. 80: 5571-5576 [Abstract] [Full Text]  
• Ch'ng, T. H., Enquist, L.W. (2005). Neuron-to-Cell Spread of Pseudorabies Virus in a Compartmented Neuronal Culture System. J. Virol. 79: 10875-10889 [Abstract] [Full Text]  
• Silva, M. C., Schroer, J., Shenk, T. (2005). Human cytomegalovirus cell-to-cell spread in the absence of an essential assembly protein. Proc. Natl. Acad. Sci. USA 102: 2081-2086 [Abstract] [Full Text]  
• Ray, N., Enquist, L. W. (2004). Transcriptional Response of a Common Permissive Cell Type to Infection by Two Diverse Alphaherpesviruses. J. Virol. 78: 3489-3501 [Abstract] [Full Text]  
• Klopfleisch, R., Teifke, J. P., Fuchs, W., Kopp, M., Klupp, B. G., Mettenleiter, T. C. (2004). Influence of Tegument Proteins of Pseudorabies Virus on Neuroinvasion and Transneuronal Spread in the Nervous System of Adult Mice after Intranasal Inoculation. J. Virol. 78: 2956-2966 [Abstract] [Full Text]  
• Labetoulle, M., Maillet, S., Efstathiou, S., Dezelee, S., Frau, E., Lafay, F. (2003). HSV1 Latency Sites after Inoculation in the Lip: Assessment of their Localization and Connections to the Eye. IOVS 44: 217-225 [Abstract] [Full Text]  
• Tomishima, M. J., Enquist, L. W. (2002). In Vivo Egress of an Alphaherpesvirus from Axons. J. Virol. 76: 8310-8317 [Abstract] [Full Text]  
• Flamand, A., Bennardo, T., Babic, N., Klupp, B. G., Mettenleiter, T. C. (2001). The Absence of Glycoprotein gL, but Not gC or gK, Severely Impairs Pseudorabies Virus Neuroinvasiveness. J. Virol. 75: 11137-11145 [Abstract] [Full Text]  
• Schmidt, J., Gerdts, V., Beyer, J., Klupp, B. G., Mettenleiter, T. C. (2001). Glycoprotein D-Independent Infectivity of Pseudorabies Virus Results in an Alteration of In Vivo Host Range and Correlates with Mutations in Glycoproteins B and H. J. Virol. 75: 10054-10064 [Abstract] [Full Text]  
• Labetoulle, M., Kucera, P., Ugolini, G., Lafay, F., Frau, E., Offret, H., Flamand, A. (2000). Neuronal Propagation of HSV1 from the Oral Mucosa to the Eye. IOVS 41: 2600-2606 [Abstract] [Full Text]  
• Labetoulle, M., Kucera, P., Ugolini, G., Lafay, F., Frau, E., Offret, H., Flamand, A. (2000). Neuronal pathways for the propagation of herpes simplex virus type 1 from one retina to the other in a murine model. J. Gen. Virol. 81: 1201-1210 [Abstract] [Full Text]  
• Gerdts, V., Beyer, J., Lomniczi, B., Mettenleiter, T. C. (2000). Pseudorabies Virus Expressing Bovine Herpesvirus 1 Glycoprotein B Exhibits Altered Neurotropism and Increased Neurovirulence. J. Virol. 74: 817-827 [Abstract] [Full Text]  
• Masse, M. J., Jöns, A., Dijkstra, J. M., Mettenleiter, T. C., Flamand, A. (1999). Glycoproteins gM and gN of Pseudorabies Virus Are Dispensable for Viral Penetration and Propagation in the Nervous Systems of Adult Mice. J. Virol. 73: 10503-10507 [Abstract] [Full Text]  
• Kim, J.-S., Enquist, L. W., Card, J. P. (1999). Circuit-Specific Coinfection of Neurons in the Rat Central Nervous System with Two Pseudorabies Virus Recombinants. J. Virol. 73: 9521-9531 [Abstract] [Full Text]  
• Banfield, B. W., Yap, G. S., Knapp, A. C., Enquist, L. W. (1998). A Chicken Embryo Eye Model for the Analysis of Alphaherpesvirus Neuronal Spread and Virulence. J. Virol. 72: 4580-4588 [Abstract] [Full Text]  
• Card, J. P., Levitt, P., Enquist, L. W. (1998). Different Patterns of Neuronal Infection after Intracerebral Injection of Two Strains of Pseudorabies Virus. J. Virol. 72: 4434-4441 [Abstract] [Full Text]  
• Anderson, A. S., Parcells, M. S., Morgan, R. W. (1998). The Glycoprotein D (US6) Homolog Is Not Essential for Oncogenicity or Horizontal Transmission of Marek's Disease Virus. J. Virol. 72: 2548-2553 [Abstract] [Full Text]  
• Tomishima, M.J., Enquist, L.W. (2001). A conserved {alpha}-herpesvirus protein necessary for axonal localization of viral membrane proteins. J. Cell Biol. 154: 741-752 [Abstract] [Full Text]