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J Virol. 1993 July; 67(7): 4369-4371

Persistence of polyomavirus in mice infected as adults differs from that observed in mice infected as newborns.

Department of Clinical Virology, Karolinska Institute, Stockholm County Council, Sweden.

ABSTRACT

By using the polymerase chain reaction (PCR) technique, a technique more sensitive than Southern analysis, which allows detection of polyomavirus DNA only in newborn and nude adult mice, it has now been possible to monitor the persistence pattern of polyomavirus DNA after infection of normal adult CBA mice for the first time. Viral signs appeared gradually, showing variations in time course and organ distribution between mice, and reached a peak activity after 2 to 3 weeks, when they could be found in bone, heart, gonads, lymph node, and skin, but disappeared by 2 to 5 months. No virus DNA was detected in the kidneys or lungs, which is in contrast to what is observed after infection of newborn mice. This finding suggests that the persistence pattern of polyomavirus is age dependent.

This article has been cited by other articles:

• Heidari, S., Krauzewicz, N., Kalantari, M., Vlastos, A., Griffin, B. E., Dalianis, T. (2000). Persistence and Tissue Distribution of DNA in Normal and Immunodeficient Mice Inoculated with Polyomavirus VP1 Pseudocapsid Complexes or Polyomavirus. J. Virol. 74: 11963-11965 [Abstract] [Full Text]