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J Virol. 1993 June; 67(6): 3601-3604

Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin.

NERC Institute of Virology, Oxford, United Kingdom.

ABSTRACT

Coexpression of human immunodeficiency virus type 1 glycoproteins with the subtilisin-like protease furin leads to processing of gp160 and gp140, a truncated form of gp160, to gp120. In addition, we show that gp120 itself is further cleaved by furin at sites near the primary cleavage site and within the V3 loop.

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