This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ohno, K Articles by Hasegawa, A Search for Related Content PubMed PubMed Citation Articles by Ohno, K Articles by Hasegawa, A

Apoptosis induced by tumor necrosis factor in cells chronically infected with feline immunodeficiency virus.

Department of Veterinary Internal Medicine, Faculty of Agriculture, University of Tokyo, Japan.

ABSTRACT

Tumor necrosis factor alpha (TNF-alpha) induced morphologic changes such as chromatin condensation and cell shrinkage in a feline fibroblastic cell line (CRFK) chronically infected with feline immunodeficiency virus (FIV) but not in uninfected CRFK cells. DNA extracted from TNF-alpha-treated CRFK cells infected with FIV showed a ladder of nucleosomal DNA, indicating that this cytocidal effect by TNF-alpha was due to programmed cell death, or apoptosis. These findings may have implications for understanding the pathogenesis of FIV infection and for the design of specific therapeutic strategies for AIDS in humans as well as cats.

This article has been cited by other articles:

• Szretter, K. J., Gangappa, S., Lu, X., Smith, C., Shieh, W.-J., Zaki, S. R., Sambhara, S., Tumpey, T. M., Katz, J. M. (2007). Role of Host Cytokine Responses in the Pathogenesis of Avian H5N1 Influenza Viruses in Mice. J. Virol. 81: 2736-2744 [Abstract] [Full Text]  
• Sanchez-Cordon, P. J., Nunez, A., Salguero, F. J., Pedrera, M., Fernandez de Marco, M., Gomez-Villamandos, J. C. (2005). Lymphocyte Apoptosis and Thrombocytopenia in Spleen during Classical Swine Fever: Role of Macrophages and Cytokines. Vet Pathol 42: 477-488 [Abstract] [Full Text]  
• Obert, L. A., Hoover, E. A. (2000). Relationship of Lymphoid Lesions to Disease Course in Mucosal Feline Immunodeficiency Virus Type C Infection. Vet Pathol 37: 386-401 [Abstract] [Full Text]  
• Klimstra, W. B., Ryman, K. D., Bernard, K. A., Nguyen, K. B., Biron, C. A., Johnston, R. E. (1999). Infection of Neonatal Mice with Sindbis Virus Results in a Systemic Inflammatory Response Syndrome. J. Virol. 73: 10387-10398 [Abstract] [Full Text]  
• Nishimura, Y., Goto, Y., Yoneda, K., Endo, Y., Mizuno, T., Hamachi, M., Maruyama, H., Kinoshita, H., Koga, S., Komori, M., Fushuku, S., Ushinohama, K., Akuzawa, M., Watari, T., Hasegawa, A., Tsujimoto, H. (1999). Interspecies Transmission of Feline Immunodeficiency Virus from the Domestic Cat to the Tsushima Cat (Felis bengalensis euptilura) in the Wild. J. Virol. 73: 7916-7921 [Abstract] [Full Text]  
• Holznagel, E., Hofmann-Lehmann, R., Leutenegger, C. M., Allenspach, K., Huettner, S., Forster, U., Niederer, E., Joller, H., Willett, B. J., Hummel, U., Rossi, G. L., Schupbach, J., Lutz, H. (1998). The Role of In Vitro-Induced Lymphocyte Apoptosis in Feline Immunodeficiency Virus Infection: Correlation with Different Markers of Disease Progression. J. Virol. 72: 9025-9033 [Abstract] [Full Text]  
• Ikeda, Y., Shinozuka, J., Miyazawa, T., Kurosawa, K., Izumiya, Y., Nishimura, Y., Nakamura, K., Cai, J., Fujita, K., Doi, K., Mikami, T. (1998). Apoptosis in Feline Panleukopenia Virus-Infected Lymphocytes. J. Virol. 72: 6932-6936 [Abstract] [Full Text]