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J Virol. 1993 April; 67(4): 2367-2369

Effect of a capsid-stabilizing pyridazinamine, R 78206, on the eclipse and intracellular location of poliovirus.

O Ofori-Anyinam, R Vrijsen, P Kronenberger and A Boeyé

Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.

ABSTRACT

R 78206 (a pyridazinamine derivative) inhibits the formation of poliovirus eclipse particles. Its effect on the intracellular location of poliovirus was studied by separating subcellular fractions in iso-osmotic Nycodenz gradients. The compound did not inhibit internalization of intact virus into small lipid vesicles, but it did inhibit the release of virus from these vesicles and its entry into lysosomes.

J Virol. 1993 April; 67(4): 2367-2369




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