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J Virol. 1993 November; 67(11): 6551-6557

Simian virus 40 large T antigen associates with cyclin A and p33cdk2.

J P Adamczewski, J V Gannon and T Hunt

ICRF Clare Hall Laboratories, South Mimms, Herts, England.

ABSTRACT

In this paper we provide evidence that a fraction of large T antigen of simian virus 40 (SV40) interacts with cyclin A and p33cdk2 in both virus-infected and stably transformed cells. Immunoprecipitates of SV40 large T antigen from SV40-infected or SV40 large-T-antigen-transformed cells contain cyclin A, p33cdk2, and histone H1 kinase activity. Conversely, immunoprecipitates of cyclin A from these cells contain SV40 large T antigen. In this respect, SV40 large T antigen has properties similar to those of the E1A oncogene of adenoviruses and the E7 oncogene of human papillomaviruses.

J Virol. 1993 November; 67(11): 6551-6557




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