This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Klein-Bauernschmitt, P Articles by Schlehofer, J R Search for Related Content PubMed PubMed Citation Articles by Klein-Bauernschmitt, P Articles by Schlehofer, J R

 Previous Article  |  Next Article 

J Virol. 1992 July; 66(7): 4191-4200

Induction of differentiation-associated changes in established human cells by infection with adeno-associated virus type 2.

Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

ABSTRACT

The nonpathogenic human defective parvovirus adeno-associated virus (AAV) type 2 induced differentiation-associated antigens in cells of the human leukemia cell line HL60 (CD 67), as well as in two different lines of immortalized human keratinocytes, HaCaT and HPK Ia cells (involucrin and cytokeratin 10). Simultaneously, expression of the c-myc and c-myb oncogenes and the retinoblastoma gene was down regulated whereas c-fos expression increased in infected cells. These data point to the potential of AAV to induce functions related to the differentiation pathway in different types of human cells. This phenomenon may be involved in the reported oncosuppressive properties of AAV infections.