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J Virol. 1992 June; 66(6): 3677-3682

A second envelope glycoprotein mediates neutralization of a pestivirus, hog cholera virus.

Federal Research Centre for Virus Diseases of Animals, Tübingen, Germany.

ABSTRACT

Several monoclonal antibodies (MAbs) raised against hog cholera virus (HCV) reacted with the HCV structural glycoprotein gp44/48 and neutralized the virus. The presence of HCV gp44/48 on the viral surface was directly demonstrated by immunogold electron microscopy. Eight anti-HCV gp44/48 MAbs were tested by immunoperoxidase assay against a panel of pestivirus strains. Each MAb showed a distinct pattern of reactivity with HCV strains. It is suggested that the MAbs are well suited for epidemiological investigations of HCV outbreaks.

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